Details

Autor(en) / Beteiligte

• Seo, Youngwan
• Hoch, Jeannine
• Abdel-Kader, Maged
• Malone, S
• Derveld, I
• Adams, Hermus
• Werkhoven, M. C. M
• Wisse, Jan H
• Mamber, Stephen W
• Dalton, James M
• Kingston, David G. I

Titel

Bioactive Saponins from Acacia te nuifolia from the Suriname Rainforest

Ist Teil von

• Journal of natural products (Washington, D.C.), 2002-02, Vol.65 (2), p.170-174

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2002

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Bioassay-guided fractionation of the MeOH extract of Acacia tenuifolia using the engineered yeast strains 1138, 1140, 1353, and Sc7 as the bioassay tool resulted in the isolation of the three new saponins 3, 5, and 6 and the three known saponins 1, 2, and 4. The structures of the new compounds were established on the basis of HRMS, 1D and 2D NMR spectral data on the intact saponins, and GC−MS analyses of the sugars. Compounds 1,2 and 5,6 showed cytotoxicity against mammalian cell lines.