Details

Autor(en) / Beteiligte

• Gansäuer, Andreas
• Bluhm, Harald
• Pierobon, Marianna

Titel

Emergence of a Novel Catalytic Radical Reaction:  Titanocene-Catalyzed Reductive Opening of Epoxides

Ist Teil von

• Journal of the American Chemical Society, 1998-12, Vol.120 (49), p.12849-12859

Ort / Verlag

American Chemical Society

Erscheinungsjahr

1998

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The preparatively important catalytic opening of epoxides to β-titanoxy radicals via single-electron transfer (SET) is described. These radicals can be reduced to alcohols or participate in C−C bond-forming reactions. A key step in the catalytic cycle is the conceptually novel protonation of titanium−oxygen and −carbon bonds. Our method combines the advantages of radical reactions, e.g., high functional group tolerance and stability of radicals under protic conditions, with the ability of organometallic complexes to determine the course of transformations in reagent-controlled reactions.