Details

Autor(en) / Beteiligte

• Kara, Selin
• Spickermann, Dominik
• Schrittwieser, Joerg H
• Weckbecker, Andrea
• Leggewie, Christian
• Arends, Isabel W. C. E
• Hollmann, Frank

Titel

Access to Lactone Building Blocks via Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactonization

Ist Teil von

• ACS catalysis, 2013-11, Vol.3 (11), p.2436-2439

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2013

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The oxidative lactonization of 1,4-, 1,5-, and 1,6-diols using horse liver alcohol dehydrogenase (HLADH) is reported. Molecular oxygen was used as terminal electron acceptor by utilization of the laccase-mediator concept to regenerate the oxidized nicotinamide cofactor and producing water as sole byproduct. Spontaneous hydrolysis of the lactone products was identified as a major limiting factor toward preparative application of the system, which can be alleviated by using a two liquid phase approach to extracting the product into an organic solvent.