Details

Autor(en) / Beteiligte

• Song, Chunlan
• Dong, Xin
• Yi, Hong
• Chiang, Chien-Wei
• Lei, Aiwen

Titel

DDQ-Catalyzed Direct C(sp3)–H Amination of Alkylheteroarenes: Synthesis of Biheteroarenes under Aerobic and Metal-Free Conditions

Ist Teil von

• ACS catalysis, 2018-03, Vol.8 (3), p.2195-2199

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A strategy for oxidative Csp3–H/N–H cross-coupling is presented. This reaction successfully utilizes 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and tert-butyl nitrite (TBN) as co-catalysts to construct the biomedical applicable biheteroarenes under aerobic conditions. Notably, this amination reaction is successful with a wide range of alkylheteroarenes and could be used as a functionalization tactic for pharmaceutical research and other areas. Furthermore, preliminary mechanistic studies indicate that the C–N bond formation proceeds through the nucleophilic attack of azole to the carbon cation.