Details

Autor(en) / Beteiligte

• Cahiez, Gérard
• Lefèvre, Guillaume
• Moyeux, Alban
• Guerret, Olivier
• Gayon, Eric
• Guillonneau, Loïc
• Lefèvre, Nicolas
• Gu, Qinzhuo
• Zhou, Edouard

Titel

Gram-Scale, Cheap, and Eco-Friendly Iron-Catalyzed Cross-Coupling between Alkyl Grignard Reagents and Alkenyl or Aryl Halides

Ist Teil von

• Organic letters, 2019-04, Vol.21 (8), p.2679-2683

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A new robust methodology for gram-scale iron-catalyzed cross-coupling between alkyl Grignard reagents and alkenyl or aryl halides is developed. This method does not require toxic additives such as NMP or expensive ligands. Its efficiency relies on the use of simple alkoxide magnesium salts as additives. On the basis of these results, a new procedure for one-pot synthesis of substituted benzamides from chloroesters is also proposed.