Details

Autor(en) / Beteiligte

• Perkins, Robert J
• Pedro, Dylan J
• Hansen, Eric C

Titel

Electrochemical Nickel Catalysis for Sp 2 -Sp 3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

Ist Teil von

• Organic letters, 2017-07, Vol.19 (14), p.3755-3758

Ort / Verlag

United States

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A constant-current electrochemical method for reducing catalytic nickel complexes in sp -sp cross-electrophile coupling reactions has been developed. The electrochemical reduction provides reliable nickel catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard activated metal powder reductants. The electrochemical reactions give yields (i.e., 51-86%) and selectivities as high or superior to those using metal powder reductants and provide access to a wider substrate scope.