Details

Autor(en) / Beteiligte

• Ge, Jing-Jie
• Yao, Chuan-Zhi
• Wang, Mei-Mei
• Zheng, Hong-Xing
• Kang, Yan-Biao
• Li, Yadong

Titel

Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp3)–C(sp2) Bonds: Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes

Ist Teil von

• Organic letters, 2016-01, Vol.18 (2), p.228-231

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A transition-metal-free deacylative C­(sp3)–C­(sp2) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and commercially abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals.