Details

Autor(en) / Beteiligte

• Volpe, Rohan
• Law, Hanson Y.-L
• White, Jonathan M
• Flynn, Bernard L

Titel

Selective Synthesis of C 1‑Symmetric BINOL-phosphates and P‑chiral Phosphoramides Using Directed ortho-Lithiation

Ist Teil von

• Organic letters, 2021-09, Vol.23 (18), p.7055-7058

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Directed ortho-lithiation (DoL) has been developed as an effective method for the ortho-substitution of BINOL-phosphoric acid and BINOL-N-triflylphosphoramide (BINOL-P-acids). It can be employed in the rapid assembly of either mono- or disubstituted BINOL-P-acids, including unsymmetrical disubstitution through iterative DoL. Most significantly, DoL has proven to be highly effective in the diastereoselective desymmetrization of pseudo-C 2 -symmetric BINOL-N-triflylphosphoramide, affording a chiral P-group.