Details

Autor(en) / Beteiligte

• Qin, Fu-Ying
• Zhang, Hao-Xing
• Di, Qian-Qian
• Wang, Yan
• Yan, Yong-Ming
• Chen, Wei-Lin
• Cheng, Yong-Xian

Titel

Ganoderma cochlear Metabolites as Probes to Identify a COX‑2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents

Ist Teil von

• Organic letters, 2020-04, Vol.22 (7), p.2574-2578

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• (±)-Dispirocochlearoids A–C (1–3), meroterpenoids with a 6/6/5/6/6/6 ring system, were isolated from Ganoderma cochlear. 1–3 are selective COX-2 inhibitors with an IC50 value of (−)-2 at 386 nM. Site-directed mutagenesis identified His351 as a COX-2 active site. In vivo anti-inflammatory activities of (−)-2 were performed against acute lung injury in mice.