Details

Autor(en) / Beteiligte

• Meng, Xianfu
• Zhang, Boyu
• Yi, Yan
• Cheng, Hui
• Wang, Baoming
• Liu, Yanyan
• Gong, Teng
• Yang, Wei
• Yao, Yefeng
• Wang, He
• Bu, Wenbo

Titel

Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT

Ist Teil von

• Nano letters, 2020-04, Vol.20 (4), p.2522-2529

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Photothermal therapy (PTT) is an efficient approach for cancer treatment. However, accurately monitoring the spatial distribution of photothermal transducing agents (PTAs) and mapping the real-time temperature change in tumor and peritumoral normal tissue remain a huge challenge. Here, we propose an innovative strategy to integrate T1-MRI for precisely tracking PTAs with magnetic resonance temperature imaging (MRTI) for real-time monitoring temperature change in vivo during PTT. NaBiF4: Gd@PDA@PEG nanomaterials were synthesized with favorable T1-weighted performance to target tumor and localize PTAs. The extremely weak susceptibility (1.04 × 10–6 emu g–1 Oe1–) of NaBiF4: Gd@PDA@PEG interferes with the local phase marginally, which maintains the capability of MRTI to dynamically record real-time temperature change in tumor and peritumoral normal tissue. The time resolution is 19 s per frame, and the detection precision of temperature change is approximately 0.1 K. The approach achieving PTT guided by multimode MRI holds significant potential for the clinical application.