Details

Autor(en) / Beteiligte

• Liu, Jianbing
• Song, Linlin
• Liu, Shaoli
• Jiang, Qiao
• Liu, Qing
• Li, Na
• Wang, Zhen-Gang
• Ding, Baoquan

Titel

A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy

Ist Teil von

• Nano letters, 2018-06, Vol.18 (6), p.3328-3334

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and a chemotherapeutic drug (doxorubicin, DOX) for combined therapy of multidrug resistant tumor (MCF-7R). This novel codelivery system, which is structurally similar to a kite, is rationally designed to contain multiple functional groups for the targeted delivery and controlled release of the therapeutic cargoes. The self-assembled DNA nanokite achieves efficient gene delivery and exhibits effective inhibition of tumor growth in vitro and in vivo without apparent systemic toxicity. These structurally and chemically well-defined codelivery nanovectors provide a new platform for the development of gene therapeutics for not only cancer but also a wide range of diseases.