Details

Autor(en) / Beteiligte

• Bertelsen, Freja
• Møller, Arne
• Folloni, Davide
• Drasbek, Kim Ryun
• Scheel-Krüger, Jørgen
• Landau, Anne M.

Titel

Increased GABA A receptor binding in amygdala after prenatal administration of valproic acid to rats

Ist Teil von

• Acta neuropsychiatrica, 2017-10, Vol.29 (5), p.309-314

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD). An altered gamma-aminobutyric acid (GABA) system may be a key factor in ASD. Here we investigated possible changes in the GABA system in rats exposed to a low dose of prenatal VPA. Method We performed autoradiography with [ 3 H]muscimol, (a GABA A receptor agonist), and [ 11 C]Ro15-4513 (a partial agonist of the GABA A α 1+5 receptor subtypes), in brain sections containing amygdala, thalamus and hippocampus of rats treated prenatally with 20 mg/kg VPA or saline from the 12th day of gestation. Result Prenatal VPA significantly increased [ 11 C]Ro15-4513 binding in the left amygdala compared with controls ( p <0.05). This difference was not observed in the hippocampus, thalamus or right amygdala. No differences were observed in [ 3 H]muscimol binding. Conclusion We observed an asymmetric increase in GABA A receptor binding. Disturbances in the GABA A receptor system have also been detected in human autism with [ 11 C]Ro15-4513.