Details

Autor(en) / Beteiligte

• Levy, Brittany
• Teplitsky, Seth
• Kalaitzoglou, Evangelia
• Kahler, Stephen
• Matheny, Juliann Paige
• Saltzman, Amanda F.

Titel

“Exogenous” 5 Alpha Reductase Deficiency: A Case Report

Ist Teil von

• Urology (Ridgewood, N.J.), 2023-08, Vol.178, p.147-150

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Testosterone and dihydrotestosterone are significant drivers of male external genital development, and therefore teratogens that alter these hormone profiles have been hypothesized to cause aberrations in development. Here, we present the first case report of genitalia anomalies after prenatal exposure to spironolactone and dutasteride through 8-weeks of gestation. The patient was born with abnormal male external genitalia which was surgically managed. Long-term outcomes such as gender identity, sexual function, hormonal maturation through puberty, and fertility remain unknown. These numerous considerations necessitate multi-disciplinary management with close follow-up to address sexual, psychological, and anatomic concerns.