Details

Autor(en) / Beteiligte

• Camunas-Alberca, Sandra M.
• Moran-Garrido, Maria
• Sáiz, Jorge
• Villaseñor, Alma
• Taha, Ameer Y.
• Barbas, Coral

Titel

The role of oxylipins and their validation as biomarkers in the clinical context

Ist Teil von

• TrAC, Trends in analytical chemistry (Regular ed.), 2023-07, Vol.164, p.117065, Article 117065

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Oxylipins are bioactive lipid mediators that participate in a wide range of processes, from blood flow to inflammation. In recent years, their exhaustive characterization as potential biomarkers has been actively pursued. However, several analytical challenges and sources of variability, like the low abundance of oxylipins in samples, their structural diversity, and the lack of harmonized and validated protocols for sample selection, collection, storage, and preparation have hampered their translation into clinical settings. In this review, these sources of variability are addressed and are exemplified with their application in recent clinical studies in different diseases. Our overall analysis highlights the need to achieve harmonized protocols for generating reliable and reproducible results that could be integrated into clinical practice to reach their full diagnostic and prognostic potential. [Display omitted] •Concept of biomarker and stages of their process until being used in clinics.•Analytical considerations for the analysis of oxylipins.•Relevant analytical solutions for isomeric oxylipins resolution.•Discussion of the method validation parameters for oxylipins.•Recent clinical studies of oxylipins.