Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Current gut-on-a-chip platforms for clarifying the interactions between diet, gut microbiota, and host health
Ist Teil von
Trends in food science & technology, 2023-04, Vol.134, p.1-12
Ort / Verlag
Elsevier Ltd
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
The interaction between diet and gut microbiota plays a critical role in human health. While the conventional in vitro models cannot faithfully recapitulate the intestinal microenvironment including multicellular architectures dynamic, tissue-tissue interfaces, flow, and shear force, which have limited the investigations on interactions between diet components and the gut. Microfluidic chip-based technology promises to overcome the limitations of conventional models by recapitulating tissue- and organ-level physiology and function.
This review focuses on summarizing the advances of gut-on-a-chip technologies and their applications for clarifying the interplay mechanisms between diet, microbiota, and host health. Model construction and major components, as well as applications of various models, are summarized and discussed.
Gut-on-a-chip could be used as a very promising tool for the evaluation of bioactive components, as well as novel food product development.
•The gut-on-a-chip technology has emerged as a very promising in vitro tool.•Deep insight into the diet-microbiota-host crosstalk is possible with the technology.•The advances in the construction of the gut-on-a-chip models are summarized.•The advantages of five classified models are discussed for food nutrition research.