Details

Autor(en) / Beteiligte

• Bakholdina, Anna
• Lukin, Alexei
• Bakulina, Olga
• Guranova, Natalia
• Krasavin, Mikhail

Titel

Dual use of propargylamine building blocks in the construction of polyheterocyclic scaffolds

Ist Teil von

• Tetrahedron letters, 2020-06, Vol.61 (24), p.151970, Article 151970

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •N-Propargyl 2-(imidazole-2-yl)indoles were investigated in cyclization reactions.•Zn(OTf)2-catalyzed reaction gave cyclization product at C-3 of the indole nucleus.•Base-promoted reaction led to cyclization at N-1 of indole.•The use of 3-aryl propargylamines gave a cascade cyclization. The cyclization reactions of 2-(N-propargyl)imidazole-2-yl)indoles (synthesized via the hydroamination reaction between N-propargyl indole-2-carboxamides and propargylamine) have been investigated under Lewis acid- and base-promoted conditions. The polyheterocyclic compounds thus obtained were shown to possess promising photophysical properties.