Details

Autor(en) / Beteiligte

• Susanto, Woen
• Kong, Kah-Hoe
• Hua, Kuo-Feng
• Wu, Shih-Hsiung
• Lam, Yulin

Titel

Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumoniae

Ist Teil von

• Tetrahedron letters, 2019-01, Vol.60 (3), p.288-291

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •Synthesis of the trisaccharide repeating unit of CPS of K. pneumoniae.•A new method for the pyruvylation of trans diol.•Stereoselective glycosylation with orthogonal protecting groups. The incidences of primary, pyrogenic liver abscess complicated by meningitis and septic endophthalmitis caused by Klebsiella pneumoniae has increased globally. Earlier studies have shown that the capsular polysaccharide (CPS) of Klebsiella pneumoniae plays an important role in the resistance to phagocytosis and related pathogenicity. The first chemical synthesis of the trisaccharide repeating unit of this CPS has been achieved via stereoselective glycosylation with orthogonal and appropriate protecting groups. A new method for the pyruvylation of trans diol was developed.