Details

Autor(en) / Beteiligte

• Phillips, Geoffrey A.
• Palmer, Cory
• Stevens, Andrew C.
• Piotrowski, Mathew L.
• Dekruyf, Daryl S.R.
• Pagenkopf, Brian L.

Titel

Oxidative cyclization of tertiary pentenol derivatives forming 2,5,5-trisubstituted THF rings and the total synthesis of cyclocapitelline

Ist Teil von

• Tetrahedron letters, 2015-10, Vol.56 (44), p.6052-6055

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] The synthesis of 2,5,5-trisubstituted tetrahydrofuran rings was accomplished via the Mukaiyama aerobic oxidative cyclization of tertiary 5-pentenols employing the Co(nmp)2 catalyst. A variety of THFs were formed in moderate to good yield and diastereoselectivity. The method developed herein was successfully applied to an enantioselective total synthesis of cyclocapitelline.