Details

Autor(en) / Beteiligte

• Kubota, Takaaki
• Sakuma, Yusuke
• Shimbo, Kazutaka
• Tsuda, Masashi
• Nakano, Michiko
• Uozumi, Yasuhiro
• Kobayashi, Jun’ichi

Titel

Amphezonol A, a novel polyhydroxyl metabolite from marine dinoflagellate Amphidinium sp

Ist Teil von

• Tetrahedron letters, 2006-06, Vol.47 (26), p.4369-4371

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2006

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Amphezonol A ( 1), a novel polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from an Okinawan marine acoel flatworm Amphiscolops sp. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Amphezonol A ( 1) possesses one tetrahydrofuran ring, two tetrahydropyran rings, and twenty-one hydroxyl groups on C 60-linear aliphatic chain with one exo-methylene and one methyl branch. Amphezonol A ( 1) exhibited a modest inhibitory activity against DNA polymerase α.