Details

Autor(en) / Beteiligte

• Barbero, Margherita
• Marabello, Domenica
• Dughera, Stefano
• Sicari, Tiziana
• Antenucci, Achille
• Ghigo, Giovanni

Titel

Diastereoselective synthesis of 3-(α-aryl)alkenylindoles from the direct dehydrative coupling of indoles and ketones: A synthetic and theoretical study

Ist Teil von

• Tetrahedron, 2020-10, Vol.76 (41), p.131498, Article 131498

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A representative library of 3-(α-aryl)alkenylindoles has been prepared via a Brønsted-acid catalysed dehydrative coupling reaction between alkyl aryl ketones and some indoles. An interesting diastereoselectivity has been observed and has been explained from a mechanistic point of view. [Display omitted] •3-(α-Aryl)alkenylindoles are easily prepared via an acid-catalysed direct dehydrative coupling between some ketones and indoles.•The observed good diastereoselectivity depending on indole substitution has been explained by a computational method.•Alkenylindoles are reactive intermediates, useful for the synthesis of indole-based heterocycles.