Details

Autor(en) / Beteiligte

• Guo, Shao-Hua
• Guo, Zhi-Qian
• Wang, Cheng-Yun
• Shen, Yongjia
• Zhu, Wei-Hong

Titel

An ultrasensitive fluorescent probe for hydrazine detection and its application in water samples and living cells

Ist Teil von

• Tetrahedron, 2019-05, Vol.75 (18), p.2642-2646

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Hydrazine, as a strong reducing agent, has been extensively used in many industrial manufactures. However, it is a potential human carcinogen and an environmental contaminant due to its high toxicity. Therefore, developing an ultrasensitive method for determining hydrazine in real water and biosystems is of great significance. Herein, based on coumarin dye, a turn-on fluorescent probe Cou-1-N2H4, which contains an acetyl group as the trigger unit and the fluorescence quencher, is developed. The probe can achieve a rapid (3min) and colorimetric sensing detection for hydrazine with an extremely low limit detection (11.9 nM or 0.38 ppb). More importantly, the practical utilities of probe have been successfully proved through quantitative N2H4 detection in environmental water samples and bioimaging of N2H4 in living cells. A coumarin-based fluorescent probe for ultrasensitive hydrazine sensing has been developed. The practical utilities of probe have been successfully proved through quantitative N2H4 detection in environmental water samples and bioimaging of N2H4 in living cells. [Display omitted] •Colorimetric and fluorescent two-output probe with dramatic responses to N2H4.•An extremely low detection limit for N2H4 determination.•Fluorescence bioimaging application in living HeLa cells.•Quantitative N2H4 detection in water samples.