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An ultrasensitive fluorescent probe for hydrazine detection and its application in water samples and living cells
Ist Teil von
Tetrahedron, 2019-05, Vol.75 (18), p.2642-2646
Ort / Verlag
Elsevier Ltd
Erscheinungsjahr
2019
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Hydrazine, as a strong reducing agent, has been extensively used in many industrial manufactures. However, it is a potential human carcinogen and an environmental contaminant due to its high toxicity. Therefore, developing an ultrasensitive method for determining hydrazine in real water and biosystems is of great significance. Herein, based on coumarin dye, a turn-on fluorescent probe Cou-1-N2H4, which contains an acetyl group as the trigger unit and the fluorescence quencher, is developed. The probe can achieve a rapid (3min) and colorimetric sensing detection for hydrazine with an extremely low limit detection (11.9 nM or 0.38 ppb). More importantly, the practical utilities of probe have been successfully proved through quantitative N2H4 detection in environmental water samples and bioimaging of N2H4 in living cells.
A coumarin-based fluorescent probe for ultrasensitive hydrazine sensing has been developed. The practical utilities of probe have been successfully proved through quantitative N2H4 detection in environmental water samples and bioimaging of N2H4 in living cells. [Display omitted]
•Colorimetric and fluorescent two-output probe with dramatic responses to N2H4.•An extremely low detection limit for N2H4 determination.•Fluorescence bioimaging application in living HeLa cells.•Quantitative N2H4 detection in water samples.