Details

Autor(en) / Beteiligte

• Romolo, Francesco Saverio
• Sarilar, Mehmet
• Antoine, Johann
• Mestria, Serena
• Strano Rossi, Sabina
• Gallidabino, Matteo Davide
• Soares de Souza, Guilherme Maurício
• Chytry, Paola
• Ferraz Dias, Johnny

Titel

Ion beam analysis (IBA) and instrumental neutron activation analysis (INAA) for forensic characterisation of authentic Viagra® and of sildenafil-based illegal products

Ist Teil von

• Talanta (Oxford), 2021-03, Vol.224, p.121829, Article 121829

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Illegal trafficking of pharmaceutical products by criminal organisations is a global threat for public health. Drugs for erectile dysfunction such as phosphodiesterase type 5 inhibitors are the most commonly counterfeited medicines in Europe. The search of possible toxic chemical substances in seized products is needed to provide early warning for public health. Furthermore, the elemental profile of the seized products can be useful in criminal investigations. For the first time an ion beam analysis (IBA) procedure to characterise authentic Viagra® tablets and sildenafil-based illegal products is described. Moreover, results are compared with the ones obtained by instrumental neutron activation analysis (INAA) on authentic Viagra® tablets in two reactors. IBA results showed that a combination of particle-induced X-ray emission (PIXE) and secondary ion mass spectrometry using primary ions with energies in the range of several MeV (MeV-SIMS) is a powerful tool to characterise different products in a straightforward manner, allowing discrimination between legal and illegal products. INAA allowed accurate elemental quantification and also showed a great potential for the future implementation of an inter-laboratory classification system. [Display omitted] •First combined approach using INAA, PIXE and MeV-SIMS for sildenafil-based products analysis.•PIXE provides elemental profiles of tablets with no sample preparation.•MeV-SIMS provides mass spectra of sildenafil with minimum sample preparation.•Both IBA and INAA discriminate between authentic Viagra® and illegal products.•An inter-laboratory classification system based on shared INAA results is possible.