Details

Autor(en) / Beteiligte

• Burin, G.R.M.
• Formiga, F.R.
• Pires, V.C.
• Miranda, J.C.
• Barral, A.
• Cabral-Albuquerque, E.C.M.
• Vieira de Melo, S.A.B.
• Braga, M.E.M.
• de Sousa, H.C.

Titel

Innovative formulations of PCL: Pluronic monoliths with copaiba oleoresin using supercritical CO2 foaming/mixing to control Aedes aegypti

Ist Teil von

• The Journal of supercritical fluids, 2022-07, Vol.186, p.105607, Article 105607

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Copaiba oleoresin (Co), a promising bioactive agent to control Aedes aegypti proliferation, was incorporated by supercritical carbon dioxide (scCO2) foaming/mixing method (SFM) in two types of poly(ε-caprolactone) (PCL), PCL45 and PCL50, using Pluronic F-68 (Plu) as a surfactant and porogenic agent. The SFM was performed at 35 °C, scCO2 densities of 750 and 850 kg m-3, soaking time of 2.5 h, and depressurization rate of 5 bar min-1. The physicochemical characterization of monoliths, the in vitro release, and larvicidal activity against A. aegypti larvae were evaluated. All monoliths with copaiba oleoresin presented larvicidal effects. The best results were observed for PCL45:Plu:Co (56:3:41) monoliths at 750 and 850 kg m-3. This result can be attributed to the higher hydrophobicity of PCL45 than PCL50. These findings indicate that copaiba oleoresin-loaded PCL:Plu:Co monoliths are innovative and sustainable materials capable of controlling the proliferation of A. aegypti larvae and insects to avoid mosquito-borne diseases. [Display omitted] •Copaiba oleoresin is a bioactive agent to control A. aegypti proliferation.•PCL-based monoliths+copaiba oleoresin was prepared by scCO2 foaming method.•Pluronic F-68 favored copaiba oleoresin release in water.•These innovative materials have potential to control larvae/insects of A. aegypti.•The control of A. aegypti avoid mosquito-borne diseases, a public health issue.