Details

Autor(en) / Beteiligte

• Saxena, Hari Om
• Faridi, Uzma
• Kumar, J.K.
• Luqman, Suaib
• Darokar, M.P.
• Shanker, Karuna
• Chanotiya, Chandan S.
• Gupta, M.M.
• Negi, Arvind S.

Titel

Synthesis of chalcone derivatives on steroidal framework and their anticancer activities

Ist Teil von

• Steroids, 2007-11, Vol.72 (13), p.892-900

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to the corresponding indanone derivative ( 19) using the Nazarov reaction, which showed better activity than the parent compound against the MCF-7 breast cancer cell line. Active anticancer derivatives were also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells.