Details

Autor(en) / Beteiligte

• Vanneste, Ben G.L
• Pijls-Johannesma, Madelon
• Van De Voorde, Lien
• van Lin, Emile N
• van de Beek, Kees
• van Loon, Judith
• Ramaekers, Bram L
• Lambin, Philippe

Titel

Spacers in radiotherapy treatment of prostate cancer: Is reduction of toxicity cost-effective?

Ist Teil von

• Radiotherapy and oncology, 2015-02, Vol.114 (2), p.276-281

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Background and purpose To compare the cost-effectiveness of treating prostate cancer patients with intensity-modulated radiation therapy and a spacer (IMRT+S) versus IMRT-only without a spacer (IMRT-O). Materials and methods A decision-analytic Markov model was constructed to examine the effect of late rectal toxicity and compare the costs and quality-adjusted Life Years (QALYs) of IMRT-O and IMRT+S. The main assumption of this modeling study was that disease progression, genito-urinary toxicity and survival were equal for both comparators. Results For all patients, IMRT+S revealed a lower toxicity than IMRT-O. Treatment follow-up and toxicity costs for IMRT-O and IMRT+S amounted to €1604 and €1444, respectively, thus saving €160 on the complication costs at an extra charge of €1700 for the spacer in IMRT+S. The QALYs yielded for IMRT-O and IMRT+S were 3.542 and 3.570, respectively. This results in an incremental cost-effectiveness ratio (ICER) of €55,880 per QALY gained. For a ceiling ratio of €80,000, IMRT+S had a 77% probability of being cost-effective. Conclusion IMRT+S is cost-effective compared to IMRT-O based on its potential to reduce radiotherapy-related toxicity.