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Manufacturing companies in high wage countries strive towards shortened development and innovation cycles at decreased costs in order to strengthen their competitive position and to support resource sustainability. Therefore, companies promote innovations through various constellations such as accelerators. Such constellations of cooperation differ in terms of time and costs and are therefore often reserved for large companies with respective monetary resources. One opportunity for smaller companies for sustainable product development is the organization of development projects within innovation ecosystems allowing innovations within networks. In order to sustainably innovate in such ecosystems, their efficient as well as effective design becomes inevitable. Thus, this paper introduces a framework to set up such ecosystems for a radical increase in innovation productivity to support industrial sustainability. To derive this framework, the idea of biological ecosystems is adapted in terms of a biological transformation. Afterwards, six activity fields are introduced, supporting the design of innovation ecosystems.