Details

Autor(en) / Beteiligte

• Müller, Talise E.
• Fontana, Barbara D.
• Bertoncello, Kanandra T.
• Franscescon, Francini
• Mezzomo, Nathana J.
• Canzian, Julia
• Stefanello, Flavia V.
• Parker, Matthew O.
• Gerlai, Robert
• Rosemberg, Denis B.

Titel

Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models

Ist Teil von

• Progress in neuro-psychopharmacology & biological psychiatry, 2020-06, Vol.100, p.109873, Article 109873

Ort / Verlag

England: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Drug abuse and brain disorders related to drug comsumption are public health problems with harmful individual and social consequences. The identification of therapeutic targets and precise pharmacological treatments to these neuropsychiatric conditions associated with drug abuse are urgently needed. Understanding the link between neurobiological mechanisms and behavior is a key aspect of elucidating drug abuse-related targets. Due to various molecular, biochemical, pharmacological, and physiological features, the zebrafish (Danio rerio) has been considered a suitable vertebrate for modeling complex processes involved in drug abuse responses. In this review, we discuss how the zebrafish has been successfully used for modeling neurobehavioral phenotypes related to drug abuse and review the effects of opioids, cannabinoids, alcohol, nicotine, and psychedelic drugs on the central nervous system (CNS). Moreover, we summarize recent advances in zebrafish-based studies and outline potential advantages and limitations of the existing zebrafish models to explore the neurochemical bases of drug abuse and addiction. Finally, we discuss how the use of zebrafish models may present fruitful approaches to provide valuable clinically translatable data. •Drug abuse and addiction affect behavioral and brain neurophysiology.•Zebrafish are suitable for modeling drug abuse-related phenotypes.•Advantages and disadvantages of zebrafish models are discussed.•The zebrafish may help explore the mechanisms underlying drug abuse and addiction.