Details

Autor(en) / Beteiligte

• Ratajczak, Piotr
• Kus, Krzysztof
• Murawiecka, Patrycja
• Słodzińska, Iwona
• Zaprutko, Tomasz
• Kopciuch, Dorota
• Paczkowska, Anna
• Nowakowska, Elżbieta

Titel

Memory deterioration based on the tobacco smoke exposure and methylazoxymethanol acetate administration vs. aripiprazole, olanzapine and enrichment environment conditions

Ist Teil von

• Pharmacology, biochemistry and behavior, 2020-02, Vol.189, p.172855, Article 172855

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Enrichment environment conditions, as well as tobacco smoke exposure, may affect cognitive function (e.g. spatial memory) in an animal model of schizophrenia and schizophrenic patients. The aim of this study was to find whether spatial memory function impairment is found in methylazoxymethanol acetate treated rats (an animal model of schizophrenia) and whether aripiprazole (1.5 mg/kg) and olanzapine (0.5 mg/kg) modify these functions. We also were able to determine whether tobacco smoke exposure and enrichment environment conditions have an impact on drug efficacy. The effect of methylazoxymethanol acetate, tobacco smoke exposure, enrichment environment and the use of drugs were studied in the Morris Water Maze test (spatial memory). The results of our study clearly show that enriched environment may have a procognitive effect while tobacco smoke and methylazoxymethanol acetate have a contradictory effect. This paper also confirmed that the use of neuroleptics, namely ARI and OLA, reduced the process of spatial memory deterioration tested in the Morris water maze both in terms of the number of escape latencies and crossed quadrants. •Tobacco smoke exposure and methylazoxymethanol acetate deteriorate memory.•Aripiprazole and olanzapine reduce deterioration of spatial memory functions.•Enriched environment conditions have a major procognitive effect.