Details

Autor(en) / Beteiligte

• Long, Guo Xian
• Lin, Jing Wen
• Liu, Dong Bo
• Zhou, Xiao Yi
• Yuan, Xiang Lin
• Hu, Guang Yuan
• Mei, Qi
• Hu, Guo Qing

Titel

Single-arm, multi-centre phase II study of lobaplatin combined with docetaxel for recurrent and metastatic nasopharyngeal carcinoma patients

Ist Teil von

• Oral oncology, 2014-08, Vol.50 (8), p.717-720

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Objectives The primarily aim of this phase II study is to evaluate the response rate (RR) and disease control rate (DCR). The secondary aim of this study is to assess the progression-free survival and overall survival of recurrent or metastatic nasopharyngeal carcinoma (NPC) patients treated with lobaplatin in combination with docetaxel. Materials and methods Patients with recurrent and metastatic NPC received docetaxel (75 mg/m2 on day 1) and lobaplatin (30 mg/m2 on day 2) every 3 weeks for two to six courses. Results From April 2011 to July 2013, 39 patients were enrolled. In total, 3 patients (7.7%) had complete response, 21 (53.8%) had partial response, 9 (23.1%) had stable disease and 4 (10.3%) had progressive disease. The overall RR was 61.5% (95% CI, 46.2–76.8%), and the DCR was 84.6% (95% CI, 73.3–95.9%). The median time to progression was 10 months (95% CI, 7.3–12.8 months) after the median follow-up duration of 10.3 months (1.5–28.9 months). The most common grade 3/4 toxicities included leucopaenia and neutropaenia (17.9%), anaemia (5.1%) and increased aminotransferase level (2.6%). Other toxicities were grade 1/2 and minimal. Conclusion Lobaplatin in combination with docetaxel demonstrated clinical activity and an acceptable toxicity profile in recurrent and metastatic NPC patients. Lobaplatin may be effective for recurrent and metastatic NPC patients who previously received cisplatin-based chemotherapy.