Details

Autor(en) / Beteiligte

• BARBOSA, Italo Oliveira
• CHILITI, Beatriz Afonso
• SHIBAKURA, Matheus Eiji Warikoda
• AULESTIA-VIERA, Patricia Verónica
• SODRÉ, Hudson Sá
• SINHORINI, Patricia Anaya
• ROCHA, André Caroli

Titel

CENTRAL GIANT CELLS GRANULOMA RECURRENCE AFTER DENOSUMAB USE: A CASE REPORT

Ist Teil von

• Oral surgery, oral medicine, oral pathology and oral radiology, 2024-06, Vol.137 (6), p.e226-e226

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Central giant cell granuloma (CGCG) is an osteolytic jaw lesion of benign nature with an unknown etiology. Treatment decisions depend on factors like the lesion's behavior, location, extent, and the patient's age. This case report describes a 28-year-old patient with an expansive CGCG located in the left mandibular body and parasymphysis, leading to facial asymmetry. Initially, the patient received six intralesional injections of triamcinolone (20mg/ml). However, due to treatment failure, denosumab therapy (120 mg) was initiated and continued for 12 months. Five months after completing denosumab therapy, a computed tomography (CT) scan revealed complete calcification of the lesion. However, six months later, a subsequent CT scan displayed radiolucent intraosseous images suggesting lesion recurrence. Surgical treatment involving curettage of the lesion was chosen. The patient has been monitored for five months post-surgery without any signs of recurrence.