Neuroscience, 2013-11, Vol.252, p.420-430
2013
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Details
- Autor(en) / Beteiligte
- Titel
- The role of HIF in cobalt-induced ischemic tolerance
- Ist Teil von
- Neuroscience, 2013-11, Vol.252, p.420-430
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Pretreatment with low concentrations of cobalt and DFO are neuroprotective. • DMOG exacerbates OGD-induced neuronal death. • Low concentrations of PHD inhibitors enhance the survival of astrocytes. • EPO, induced by HIF in astrocytes, may underlie protection. • However, over activation of HIF in these cultures may activate pro-death pathways.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2013.07.060Titel-ID: cdi_crossref_primary_10_1016_j_neuroscience_2013_07_060
- Format
- –
- Schlagworte
- Amino Acids, Dicarboxylic - pharmacology, Animals, Astrocytes - drug effects, Astrocytes - metabolism, Astrocytes - pathology, Biological and medical sciences, Brain Ischemia - metabolism, Cell Survival - drug effects, Cell Survival - physiology, Cells, Cultured, cobalt, Cobalt - pharmacology, Deferoxamine - pharmacology, DFO, DMOG, Erythropoietin - biosynthesis, Fundamental and applied biological sciences. Psychology, hippocampal cultures, Hippocampus - drug effects, Hippocampus - metabolism, Hippocampus - pathology, Hypoxia-Inducible Factor 1 - biosynthesis, Immunohistochemistry, Ischemic Preconditioning, Mice, Mice, Inbred C57BL, Neurology, Neurons - drug effects, Neurons - metabolism, Neurons - pathology, neuroprotection, Neuroprotective Agents - pharmacology, Polymerase Chain Reaction, Prolyl-Hydroxylase Inhibitors - pharmacology, Vertebrates: nervous system and sense organs