Details

Autor(en) / Beteiligte

• Nnabuike, Ginikachukwu Grace
• Meena, Surya Nandan
• Palake, Ashwini R.
• Kodam, Kisan M.
• Salunke-Gawali, Sunita
• Butcher, Ray J.
• Obaleye, Joshua Ayoola

Titel

Zn(II) complexes with mefenamic acid: Synthesis, characterization, and anticancer activity

Ist Teil von

• Journal of molecular structure, 2023-12, Vol.1294, p.136432, Article 136432

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Zinc (II) complexes of mefenamic acid are synthesized.•The complexes were structurally characterized using SCXRD.•Cytotoxic activity evaluated by MTT assay against MCF-7.•The ionic complex (2) demonstrated the highest anticancer activity. In this study, three Zn(II) complexes were synthesized by reacting Zn(CH3COO)2· 2H2O or Zn(ClO4)2· 6H2O with mefenamic acid in the presence of imidazole and pyridine-based co-ligands. The resulting complexes were [Zn(mef)2(imi)2]; (1), [Zn(mef)(py)3]· (ClO4); (2), and [Zn3(mef)6(apy)2]; (3), where mef represents deprotonated mefenamic acid/mefenamato, imi represents imidazole, py represents pyridine and apy represents 2-aminopyridine. Elemental analysis, spectroscopic techniques (FTIR, UV–Vis, 1H and 13C NMR, fluorescence), PXRD (1) and (3), thermal analysis (TG-DSC) (1) and (3), and single crystal X-ray crystallography were employed to characterize the complexes. The Zn(II) in (1) and (2) are in a distorted tetrahedral coordination environment. In (1), the Zn(II) is coordinated by two mefenamato ligands, each coordinating via a monodentate carboxylate oxygen atom and two nitrogens of the imidazole ligands. In (2), the Zn(II) is coordinated by one mefenamato and three pyridine ligands. Complex (3) is a trinuclear zinc complex in which the central Zn(II) is coordinated by six oxygen atoms from six bridging carboxylate groups of the mefenamato ligands. Three mefenamato ligands and a monodentate 2-aminopyridine ligand also coordinate to two terminal Zn(II) ions in a tetrahedral coordination environment in (3). The cytotoxicity of the complexes was evaluated using an MTT assay against MCF-7 (human breast cancer cell line). The complexes demonstrated dependent cell cytotoxicity, with (2) showing the highest anticancer activity. [Display omitted]