Details

Autor(en) / Beteiligte

• Paramasivaganesh, Kumaraswamy
• Narayanan, Vimalasruthi
• Ganesan, Vigneshkumar
• shanmugasundram, Esakkimuthu
• Rajamohan, Rajaram
• Lee, Yong Rok
• Thambusamy, Stalin

Titel

Inclusion complexation of biphenyl-3,3′,4,4′-tetraamine and 4,4′-diaminobiphenyl-3,3′-diol with β-cyclodextrin for antibacterial activity

Ist Teil von

• Journal of molecular structure, 2023-10, Vol.1289, p.135866, Article 135866

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •The ICs analyzed by the UV, fluorescence, and CV techniques.•The ICs with 1:1 and 1:2 ratios and binding constant are calculated.•The potential of BPT & DABD is high with β-CD & confirms the formation of ICs.•The chemical shifts of BPT and DABD have altered much in ICs.•ICs tested on E. coli & S.aureus and observed improved activity. Inclusion complex (IC) of β-cyclodextrin (β-CD) with biphenyl-3,3′,4,4′-tetraamine (BPT), and 4,4′-diaminobiphenyl-3,3′-diol (DABD) are prepared and investigated in both solution and solid state. The effect of β-CD on the enhancement of solubility, stability, and antibacterial activity of poorly water-soluble BPT and DABD. Ultraviolet (UV), Fluorescence (FL), and Cyclic Voltammetric (CV) methods are particularly useful for determining stoichiometric ratios and binding constants in liquids. The prepared solid-phase ICs between host and guest are confirmed by powder XRD, SEM, DTA, FT-IR, and 1HNMR results. These results revealed that both BPT and DABD molecules formed ICs with β-CD with the stoichiometric ratio of 1:1.In this case, structurally confirmed ICs are required for investigating antibacterial activity, and their biological properties are as expected. It is widely acknowledged that these ICs recommended to the pharmaceutical and food industry due to their effective solubility, stability, and antibacterial activity. [Display omitted]