Details

Autor(en) / Beteiligte

• Rajamohan, Rajaram
• Ashokkumar, Sekar
• Lee, Yong Rok

Titel

Environmental free synthesis of biologically active Cu2O nanoparticles for the cytotoxicity

Ist Teil von

• Journal of molecular structure, 2023-01, Vol.1271, p.134081, Article 134081

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• •Cu2O NPs were synthesized via a greener route and HP-β-CD was used as a capping agent.The synthesized NPs have cubic in nature confirmed by XRD patterns.•EDX pattern displays the NPs were crystalline.•TEM images evident NPs having an average size of 33.2 nm.The composition of Cu and O in NPs was found by XPS technique.•There is no significant cell apoptosis for the NPs in the FACS approach. Using a simple greener and environmentally free method for the synthesis of cuprous oxide nanoparticles (Cu2O NPs), the effect of Hydroxypropyl-β-cyclodextrin (HP-β-CD) as a capping agent has also been analyzed in detail. In order to produce the NPs, the copper sulfate in aqueous solutions is reduced with L-ascorbic acid and capped with HP-β-CD. Energy-dispersive X-ray spectroscopy (EDX) and X-ray Photoelectron spectroscopy (XPS) are used for the elemental analysis whereas field emission scanning electron microscopy (FE-SEM), and high-resolution tunneling electron microscopy (HR-TEM) are carried out for the analysis of surface morphology of the prepared NPs. In the typically selected area electron diffraction (SAED) pattern along with the lattice fringes, the crystalline structure of NPs could be described as face-centered cubic (FCC) with cu (111), (200), and (220) lattice planes. In addition, HR-TEM images are evident for the Cu2O NPs and revealed that the spherical with an average size of 33.2 nm. In-vitro cytotoxic ability with the NPs has been tested on the MDA-MB-231 (human breast cancer cell) cells and it was revealed to attain nearly 50% toxicity in 2.0 mg/ml (50% cell survival) and other concentrations attained 90-98% survival and a similar pattern is expressed in FACS analysis. [Display omitted]