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Synthesis of novel 6-substituted-5,6-Dihydrobenzo[4,5] Imidazo[1,2-c] quinazoline compounds and evaluation of their properties
Ist Teil von
Journal of molecular structure, 2019-10, Vol.1193, p.482-494
Ort / Verlag
Elsevier B.V
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
New 6-substituted-5,6-dihydrobenzo[4,5] imidazo[1,2-c] quinazoline compounds were synthesized using two different protocols: microwave-enhanced and classical heating methods. A comparison study that was set up to compare both the methods and the results showed that the microwave-assisted method produced a better percentage yield (up to 98%) in a very short reaction time (only a few minutes). All compounds were characterized by spectroscopic and elemental analysis. Only one compound was analyzed by single crystal X-ray diffraction despite the difficulties of getting good crystal even after several attempts. The X-ray crystallography results were chemically acceptable and confirmed the structure of benzimidazoquinazoline 5. Incidentally, the studied derivatives were found to emit a very nice blue light when exposed to UV-light. Therefore, a photoluminescence study was performed as a part of the characterization processes. Biological application as an antimicrobial and an antioxidant for the target analogues was performed. Some derivatives exhibited high antibacterial activity against studied Gram-positive strains, although they were not active against Gram-negative strains. Moreover, some of them showed excellent antioxidant activities against both of the studied antioxidant DPPH• and ABTS•+ radicals.
•Novel compounds were synthesized by microwave-enhanced and classical heating methods.•Microwave-assisted method produced better percentage yield (reach up to 98%) in very short reaction time.•Biological application as antimicrobial and antioxidant for the target analogues was performed.•Compounds excellent antioxidant activities against both of the studied antioxidant DPPH.• and ABTS•+ radicals.