Details

Autor(en) / Beteiligte

• Schreiner, Tatiana B.
• Santamaria-Echart, Arantzazu
• Colucci, Giovana
• Plasencia, Paula
• Santos Costa, Patrícia
• Dias, Madalena M.
• Pinho, Simão P.
• Filomena Barreiro, Maria

Titel

Saponin-based natural nanoemulsions as alpha-tocopherol delivery systems for dermal applications

Ist Teil von

• Journal of molecular liquids, 2023-12, Vol.391, p.1-12, Article 123371

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Vitamin E all-natural nanoemulsion systems were developed.•Highly stable systems were produced from saponin-based emulsifiers.•Photodegradation profiles corroborated effective Vitamin E UV protection.•Ex vivo skin permeation studies revealed excellent Vitamin E-delivering capacity.•The developed solutions can be proposed as green-labelled cosmetical products. Nanoemulsions can be produced using simple methods and compounds from natural sources. They can increase water dispersibility and bioavailability and optimise active ingredient dispersion in particular skin layers. Lipophilic compounds of the vitamin E family (tocopherols and tocotrienols) are well-known for their high antioxidant activity and capacity to protect the skin from oxidative stress. In this context, oil-in-water (o/w) nanoemulsions with and without α-tocopherol (Vitamin E, VE) were formulated with two emulsifier alternatives, Quillaja saponin (QS), and a combination of QS with Tribulus terrestris (QSTT) (50/50, w/w). The emulsions were evaluated concerning stability, microstructure, droplet size, colour attributes, encapsulation efficiency, UV photostability, antioxidant activity, and in vitro permeation studies to assess the delivery potential. Results showed highly stable systems, with round-shape droplets of 80–121 nm size. QS and QSTT samples' colours were close to white and light brownish, respectively. The topical nano cream had the capacity to entrap VE, producing a protective effect from UV degradation, and very significant antioxidant activity, with IC50 values around 0.01 %wt. The skin permeation profiles showed the efficiency of the formulations in the delivery of VE, with permeabilities between 64 and 74 µg/cm2, while the control sample showed no VE permeation.