Details

Autor(en) / Beteiligte

• Rajamohan, Rajaram
• Mohandoss, Sonaimuthu
• Ashokkumar, Sekar
• Choi, Eun Ha
• Madi, Fatiha
• Leila, Neour
• Lee, Yong Rok

Titel

Water-soluble inclusion complexes for a novel anti-viral agent with low toxicity; Oseltamivir with the β-cyclodextrins

Ist Teil von

• Journal of molecular liquids, 2022-11, Vol.366, p.120297, Article 120297

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •To get ICs with a potential antiviral agent, sonication has been explored.•Changes in morphology after making ICs are clearly visualized by SEM.•ICs are confirmed by atomic percentages and binding energy by XPS analysis.•Water-soluble OTV:H-CD-ICs produced less syncytium than ICs with B-CD.•ICs revealed the survival and good for virus inactivation than OTV. An innovative sonication method has been developed to produce inclusion complexes (ICs) of Oseltamivir (OTV) which is a potentially water-soluble anti-viral agent with lesser cytotoxicity. Proton signals and chemical shifts of OTV without any ambiguity confirm the formation of ICs with β-Cyclodextrin (B-CD) and Hydroxypropyl-β-cyclodextrin (H-CD). ICs are also supported by their atomic percentages as secondary evidence using XPS analysis. Analysis of drug release at three pH levels revealed the slow release of the OTV from ICs and also suitable for viral inactivation. A very less cytotoxic ability on cancer cell lines and enhanced the viral inactivation of OTV after being made into water-soluble ICs.