Details

Autor(en) / Beteiligte

• Gibadullina, Elmira M.
• H. B. Nguyen, Tran
• Nguyen, Thu T.
• Strelnik, Anna G.
• Voloshina, Alexandra D.
• Lyubina, Anna P.
• Amerhanova, Sumbel K.
• Burilov, Alexander R.

Titel

Synthesis of new p-quinone methide containing morpholine fragment: access to (diarylmethyl)phosphonamidates with antitumor activity

Ist Teil von

• Mendeleev communications, 2023-03, Vol.33 (2), p.234-236

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Beschreibungen/Notizen

• [Display omitted] Novel (diarylmethyl)phosphonamidates containing 2,6-di-tert-butylphenol and heterocycle moieties were synthesized by 1,6-conjugate addition of phosphorylated p-quinone methide with morpholine fragment to 2,6-diaminopyridine or 1,3-diaminobenzene. In the case of an acid-catalyzed reaction of p-quinone methide with sesamol, morpholine was cleaved to form 1,2-benzoxaphosphole substituent. Cytotoxic effects of starting compounds and obtained products were evaluated towards human cancer and normal cells.