Details

Autor(en) / Beteiligte

• De Spiegeleer, Anton
• Kahya, Hasan
• Crombez, Liesbeth
• Descamps, Amelie
• Rössler, Roland
• Kressig, Reto W.
• Lapauw, Bruno
• Wynendaele, Evelien
• Elewaut, Dirk
• De Spiegeleer, Bart
• Van Den Noortgate, Nele

Titel

Potential role of statins in treatment of acute sarcopenia

Ist Teil von

• Medical hypotheses, 2023-08, Vol.177, p.111111, Article 111111

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Accelerated muscle aging, known as sarcopenia, is a geriatric condition that poses significant health risks both for individuals and society. Hospitalization can trigger a sudden deterioration of sarcopenia, making it imperative to find effective interventions targeting this acute sarcopenia. Drug repurposing, which involves utilizing ‘old’ medications for new indications, could be a cost-effective and faster solution as the safety of these drugs has already been established in the old population. The authors propose that short-term use of low-dose statins may be a promising option for preventing and treating acute sarcopenia. This hypothesis is based on the mechanisms of action of statins, which demonstrate hormesis-like effects with no direct muscle-toxic effects at low doses, as well as muscle-beneficial indirect effects through other body systems such as the immune-endothelial system and the gut microbiota at low doses. Additionally, supportive observational studies suggest beneficial muscle effects in inflammatory subgroups of older people, with a safe track record of statins in older people at short-term low doses. Therefore, it is hypothesized that statins may be of potential benefit in combating acute sarcopenia.