Details

Autor(en) / Beteiligte

• Jacobsen, Henning
• Walendy-Gnirß, Kerstin
• Tekin-Bubenheim, Nilgün
• Kouassi, Nancy Mounogou
• Ben-Batalla, Isabel
• Berenbrok, Nikolaus
• Wolff, Martin
• dos Reis, Vinicius Pinho
• Zickler, Martin
• Scholl, Lucas
• Gries, Annette
• Jania, Hanna
• Düsedau, Arne
• Pilnitz-Stolze, Gundula
• Jeridi, Aicha
• Yildirim, Ali Ö.
• Fuchs, Helmut
• Gailus-Durner, Valerie
• Stoeger, Claudia
• de Angelis, Martin Hrabe
• Manuylova, Tatjana
• Klingel, Karin
• Culley, Fiona J.
• Behrends, Jochen
• Loges, Sonja
• Schneider, Bianca
• Krauss-Etschmann, Susanne
• Openshaw, Peter
• Gabriel, Gülsah

Titel

Offspring born to influenza A virus infected pregnant mice show increased vulnerability to viral and bacterial infections in early life

Ist Teil von

• Journal of reproductive immunology, 2023-09, Vol.159, p.104003, Article 104003

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Influenza during pregnancy can affect offspring’s health in later life, of which neurocognitive disorders are among the best described. In this study, we sought to understand whether maternal influenza might have adverse effects on immune responses in offspring. Using a novel two-hit murine model, we assessed the impact of maternal influenza A virus infection (first hit) on offspring´s vulnerability to heterologous infections (second hit) in later life. We found that offspring born to influenza A virus infected mothers were stunted and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection was especially marked in neonates and was associated with multiple deficiencies. In particular, alveolar macrophages of offspring exposed to maternal influenza showed reduced capacity to clear second hit pathogens. This impaired pathogen clearance could be partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza may impair offspring´s immune ontogeny and increase vulnerability to early life infections.