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Synthesis and anticancer evaluation of mono- and trinuclear half-sandwich rhodium(III) and iridium(III) complexes based on N,O-salicylaldiminato-sulfonated scaffolds
Ist Teil von
Journal of organometallic chemistry, 2017-10, Vol.846, p.100-104
Ort / Verlag
Elsevier B.V
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Mononuclear and trinuclear half-sandwich Rh(III) and Ir(III) complexes based on a sulfonated scaffold have been synthesised and characterised using NMR and IR spectroscopy, mass spectrometry and elemental analysis. The cytotoxicities of the compounds were evaluated against the WHC01 oesophageal cancer cell line, with a slight increase in activity observed upon coordination of the metal.
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•Mono- and trinuclear half-sandwich Rh(III) and Ir(III) complexes based on sulfonated scaffolds have been prepared.•The complexes were characterized using several spectroscopic and analytical techniques.•Complexes were screened against the WHC01 oesophageal cancer cell line.•A slight increase in activity is observed upon metal coordination.