Details

Autor(en) / Beteiligte

• Casas, José S.
• Castellano, Eduardo E.
• Couce, María D.
• Ellena, Javier
• Sánchez, Agustín
• Sordo, José
• Taboada, Carmen

Titel

A gold(I) complex with a vitamin K3 derivative: Characterization and antitumoral activity

Ist Teil von

• Journal of inorganic biochemistry, 2006-11, Vol.100 (11), p.1858-1860

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2006

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Reaction of the vitamin K3 derivative menadione sodium bisulfite thiosemicarbazone (NaK3TSC) with chloro(triethylphosphine)gold(I) afforded the complex [AuPEt3(K3TSC)]. This compound consists of discrete molecules in which the metal is almost linearly coordinated to P and S. Preliminary in vitro screening showed significant anti-cancer activity, notably against the cisplatin-resistant cell line A2780cis.