Journal of inorganic biochemistry, 2005-08, Vol.99 (8), p.1646-1652
2005
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Synthesis, characterization and biological activity of triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates
- Ist Teil von
- Journal of inorganic biochemistry, 2005-08, Vol.99 (8), p.1646-1652
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2005
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- The triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates, 2-PhC 2N 3CO 2SnR 3 (R = C 6H 5, 1; c-C 6H 11, 2; C 6H 5C(CH 3) 2CH 2, 3), have been prepared and characterized by means of elemental analysis, IR and NMR ( 1H, 13C and 119Sn) spectroscopy. The crystal structures of 1 and 3 have been determined. Compound 1 is polymeric in nature with a trigonal bipyramidal configuration, and compound 3 shows a tetrahedral geometry. Bioassay results have shown that these compounds have good antibacterial and antitumor activity. The activity against three human tumor cell lines (HeLa, CoLo205 and MCF-7) decreased in the order 1 > 2 > 3.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0162-0134eISSN: 1873-3344DOI: 10.1016/j.jinorgbio.2005.05.006Titel-ID: cdi_crossref_primary_10_1016_j_jinorgbio_2005_05_006
- Format
- –
- Schlagworte
- 2-Phenyl-1,2,3-triazole-4-carboxylic acid, Anti-Bacterial Agents - chemical synthesis, Anti-Bacterial Agents - chemistry, Anti-Bacterial Agents - pharmacology, Antibacterial activity, Antineoplastic Agents - chemical synthesis, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, Antitumor activity, Azoles - chemistry, Carboxylic Acids - chemistry, Cell Line, Tumor, Cell Proliferation - drug effects, Crystal structure, Crystallography, X-Ray, Escherichia coli - drug effects, Humans, Inhibitory Concentration 50, Magnetic Resonance Spectroscopy, Molecular Conformation, Organotin carboxylate, Organotin Compounds - chemical synthesis, Organotin Compounds - chemistry, Organotin Compounds - pharmacology, Spectrophotometry, Infrared, Streptococcus - drug effects