Details

Autor(en) / Beteiligte

• Huang, Lei
• Qiu, Zhili
• Wang, Shu

Titel

Prevention and mechanism effect of Zn(II) coordination complex on oral implant restoration

Ist Teil von

• Journal of the Indian Chemical Society, 2022-07, Vol.99 (7), p.100536, Article 100536

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this study, by reaction of Zn(NO3)2·6H2O with HL ligand under a slow evaporation reaction condition, a novel mononuclear Zn(II) complex [Zn(L)2]·C2H5OH (1) with tetrahedral coordination geometry has been created by employment of an adamantan-type Schiff-base ligand 2-(adamantan-1-ylimino)methyl-4-methylphenol (HL). Its application values against the recurrent infection after oral implants were evaluated with ELISA assay and real time RT-PCR assay. The Zn(II) complex toxicity was evaluated in this research with CCK-8 assay. The molecular docking simulation confirmed that the adamantane functional group applied a hindrance effect on the connected nitrogen atom and therefore, the oxygen atom on the hydroxyl functional group could form binding interaction with receptor as expected.