Details

Autor(en) / Beteiligte

• Liu, Zhi-Chao
• Wng, Qian
• Zheng, Qi
• Zhao, Wen-Li
• Chen, Cheng
• Ruan, Ling-Yu
• Xu, Han
• Meng, Hui-Hui
• Zhao, Wen-Long
• Liu, Wen-Ya
• Zhong, Jia-Ge
• Luo, Bu-zha-xi
• Norbu, Kelsang
• Zhou, Feng
• Wang, Jun-Song
• Feng, Xin

Titel

Acute hepatotoxicity and nephrotoxicity risk assessment of the Tibetan medicine 25 flavors of the turquoise pill based on 1H-NMR metabonomics

Ist Teil von

• Journal of ethnopharmacology, 2021-10, Vol.279, p.113916, Article 113916

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• 25 flavors of the turquoise pill, a traditional Tibetan medicine for the treatment of various types of hepatitis, has not been investigated on its safety, especially the component mineral turquoise, which is believed to be essential but worried for its potential toxicity. Aim of the study: To explore the potential acute toxicity and function of 25 flavors of the turquoise pill and turquoise, the possible mechanism of the effects of turquoise and 25 flavors of the turquoise pill were systematically studied based on 1H NMR metabolomics. The rats were administered with turquoise and 25 flavors of the turquoise pill by gavage for 7 days, and samples of serum, liver, and kidney were collected. The potential toxicity and function of turquoise and 25 flavors of the turquoise pill on the liver and kidney of SD rats were evaluated by 1H NMR metabonomics, histopathology, and biochemical indexes. The results demonstrated that 25 flavors of the turquoise pill could scavenge free oxygen radicals, strengthen aerobic respiration and inhibit glycolysis in the liver. It did not cause oxidative stress in the kidney with no obvious damage. By modulation of branched-chain amino acids (BCAAs), 25 flavors of the turquoise pill can improve the utilization of glucose and promote aerobic respiration of the kidney. Considering the high dosage and short duration used in this study relative to their typical clinical usage, administration of 25 flavors of the turquoise pill and its component mineral turquoise are safe to livers and kidneys. [Display omitted] •The drug safety of turquoise and 25 flavors of the turquoise pill in rats were firstly studied by 1H NMR-based metabolomics.•25 flavors of the turquoise pill can promote the aerobic respiration of the kidney and liver in rats.•Considering the large dosage used in this experiment, both 25 flavors of the turquoise pill and turquoise are safe.