Details

Autor(en) / Beteiligte

• Shabeena, M.
• Kouser, Sabia
• Prabhu, Ashwini
• Nagaraja, G.K.
• Warale, Deepali
• Manasa, D.J.

Titel

Biocompatible pectin-functionalised-halloysite loaded poly(vinyl alcohol) nanocomposite films for tissue engineering applications

Ist Teil von

• Journal of drug delivery science and technology, 2023-04, Vol.82, p.104320, Article 104320

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The present study brings out the affirmative knowledge on covalently modified halloysite nanotube (HNT) with the biopolymer pectin and their poly (vinyl alcohol) nanocomposite films. The kaolin grouped HNTs have rooted a path for incorporation of pectin-functionalised-HNTs (Pec-f-HNT) into a PVA matrix. The as modified HNTs and polymer nanocomposite films were characterised by using FTIR, SEM, AFM, XRD and TGA. Furthermore, the nanocomposite films have been subjected for UTM; swelling as well as enzymatic degradation in-vitro. The morphological studies have revealed the increased ability of the polymer films compared to plane PVA towards surface roughness with increasing percentage of pectin-functionalised HNTs. In addition, the behaviour of films towards water molecules was established by contact angle measurements. Hemocompatibility has driven a step forward to being all the films heme-protective. The polymer nanocomposite films along with plane PVA were followed up for cell adhesion and cell proliferation with mouse fibroblast (NIH3T3) cells and the results have been confirmed their potential usability in tissue engineering applications. [Display omitted] •The grafting of biopolymer pectin onto the halloysite surface makes it more efficient filler for the fabrication of PVA nanocomposite films.•Pectin and HNT enhance the thermal, mechanical and physicochemical nature of prepared films and proves them to be viable in physiological environment.•The nanocomposite films have shown an appreciable amount of cell growth and proliferation when tested with NIH3T3 mouse fibroblast.•Blood compatibility assay has revealed the non-hemolytic nature of nanocomposite films in physiological condition.