Details

Autor(en) / Beteiligte

• Ding, Hang
• Xu, Kun
• Zeng, Cheng-Chu

Titel

Nickel-catalyzed electrochemical Minisci acylation of aromatic N-heterocycles with α-keto acids via ligand-to-metal electron transfer pathway

Ist Teil von

• Journal of catalysis, 2020-01, Vol.381, p.38-43

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2020

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •The first example of Ni-catalyzed Minisci acylation reaction was developed.•This protocol avoids using external chemical oxidants.•A ligand-to-metal electron transfer process was observed. A nickel-catalyzed electrochemical methodology for the Minisci acylation of aromatic electron-deficient heterocycles with α-keto acids has been developed. The reaction is performed in an undivided cell under constant current conditions, featuring broad scope of substrates and avoiding the conventional utilization of silver-based catalysts in conjunction with excess amount of oxidants. Cyclic voltammetric analysis disclosed that a ligand-to-metal electron transfer process may be involved in the generation of the key acyl radicals.