Details

Autor(en) / Beteiligte

• Postema, Pieter G., MD
• van Dessel, Pascal F.H.M., MD, PhD
• Kors, Jan A., PhD
• Linnenbank, Andre C., PhD
• van Herpen, Gerard, MD, PhD
• Ritsema van Eck, Henk J., MD, PhD
• van Geloven, Nan, MSc
• de Bakker, Jacques M.T., PhD
• Wilde, Arthur A.M., MD, PhD
• Tan, Hanno L., MD, PhD

Titel

Local Depolarization Abnormalities Are the Dominant Pathophysiologic Mechanism for Type 1 Electrocardiogram in Brugada Syndrome

Ist Teil von

• Journal of the American College of Cardiology, 2010-02, Vol.55 (8), p.789-797

Ort / Verlag

Elsevier Inc

Erscheinungsjahr

2010

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Objectives We sought to obtain new insights into the pathophysiologic basis of Brugada syndrome (BrS) by studying changes in various electrocardiographic depolarization and/or repolarization variables that occurred with the development of the signature type 1 BrS electrocardiogram (ECG) during ajmaline provocation testing. Background BrS is associated with sudden cardiac death. Its pathophysiologic basis, although unresolved, is believed to reside in abnormal cardiac depolarization or abnormal repolarization. Methods Ajmaline provocation was performed in 269 patients suspected of having BrS with simultaneous recording of ECGs, vectorcardiograms, and 62-lead body surface potential maps. Results A type 1 ECG was elicited in 91 patients (BrS patients), 162 patients had a negative test result (controls), and 16 patients had an abnormal test result. Depolarization abnormalities were more prominent in BrS patients and were mapped to the right ventricle (RV) by longer right precordial filtered QRS complex durations (142 ± 23 ms vs. 125 ± 14 ms, p < 0.01) and right terminal conduction delay (60 ± 11 ms vs. 53 ± 9 ms, p < 0.01). Repolarization abnormalities remained concordant with depolarization abnormalities as indicated by steady low nondipolar content (12 ± 8% vs. 8 ± 4%, p = NS), lower spatial QRS-T integrals (33 ± 12 mV·ms vs. 40 ± 16 mV·ms, p < 0.05), similar spatial QRS-T angles (92 ± 39° vs. 87 ± 31°, p = NS), similar Tpeak -Tend interval (143 ± 36 ms vs. 138 ± 25 ms, p = NS), and similar Tpeak -Tend dispersion (47 ± 37 ms vs. 45 ± 27 ms, p = NS). Conclusions The type 1 BrS ECG is characterized predominantly by localized depolarization abnormalities, notably (terminal) conduction delay in the RV, as assessed with complementary noninvasive electrocardiographic techniques. We could not define a separate role for repolarization abnormalities but suggest that the typical signs of repolarization derangements seen on the ECG are secondary to these depolarization abnormalities.