Details

Autor(en) / Beteiligte

• Nagai, Hiroaki
• Suzuki, Susumu
• Ishii, Hideki
• Shibata, Yohei
• Harata, Shingo
• Takayama, Yohei
• Tatami, Yosuke
• Shimbo, Yusaku
• Osugi, Naohiro
• Ota, Tomoyuki
• Kawamura, Yoshihiro
• Tanaka, Akihito
• Takeshita, Kyosuke
• Murohara, Toyoaki

Titel

Impact of low-grade albuminuria on left ventricular diastolic dysfunction

Ist Teil von

• IJC metabolic & endocrine, 2015-03, Vol.6, p.13-16

Ort / Verlag

Elsevier Ireland Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Abstract Background Albuminuria is an established risk factor for mortality and cardiovascular events in high-risk populations. However, few studies have evaluated the relationship between normoalbuminuria and left ventricular (LV) diastolic function. The present study evaluated the impact of the low-grade albuminuria on LV diastolic function in patients with coronary artery disease (CAD). Methods A cross-sectional study was conducted in 202 chronic CAD patients with normal urinary albumin levels. Subjects were divided into 3 tertiles according to sex-specific urinary albumin-to-creatinine concentration ratio (UACR) cut-off points. Subjects in the upper tertile were classified as having low-grade albuminuria. To evaluate the LV function, all subjects underwent echocardiography. LV diastolic dysfunction was defined as E/e′ > 15 or 8 < E/e′ < 15, with an E/A < 0.5, a deceleration time > 280 ms, and a LV mass index > 122 g/m2 for women or > 149 g/m2 for men. Results Among the 202 patients, 76 patients (37.6%) had LV diastolic dysfunction. The prevalence of LV diastolic dysfunction in the upper tertile was significantly greater than that in the middle and lower tertiles (49.3%, 32.3% and 29.2%, respectively; p for trend = 0.029). Adjusting for confounding factors, the presence of low-grade albuminuria independently associated with LV diastolic dysfunction (odds ratio 2.22, 95% confidence interval: 1.05–4.71, p = 0.037). Conclusions A high UACR level that is still below the current microalbuminuria threshold is significantly associated with an increased prevalence of LV diastolic dysfunction in CAD patients. Our data suggest that low-grade albuminuria in high-risk populations may provide greater cardiovascular risk stratification.