Details

Autor(en) / Beteiligte

• Prada, Patrícia Oliveira
• Pauli, José Rodrigo
• Ropelle, Eduardo Rochete
• Zecchin, Henrique Gottardello
• Carvalheira, José Barreto Campello
• Velloso, Lício Augusto
• Saad, Mario José Abdalla

Titel

Retracted: Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats

Ist Teil von

• FEBS letters, 2006-09, Vol.580 (20), p.4889-4894

Erscheinungsjahr

2006

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• A high‐fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3‐K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin‐induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.